HSV is the most common cause of viral encephalitis.

When infecting the brain, the virus shows a preference for the temporal lobe.

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Even microscopic abrasions on mucous membranes are sufficient to allow viral entry.

HSV asymptomatic shedding occurs at some time in most individuals infected with herpes.

During immunodeficiency, herpes simplex can cause unusual lesions in the skin.

One of the most striking is the appearance of clean linear erosions in skin creases, with the appearance of a knife cut.

The virus interacts with the components and receptors of lipoproteins, which may lead to its development.

Herpes transmission occurs between discordant partners; a person with a history of infection (HSV seropositive) can pass the virus to an HSV seronegative person.Herpes whitlow is a painful infection that typically affects the fingers or thumbs.On occasion, infection occurs on the toes or on the nail cuticle.In all cases, HSV is never removed from the body by the immune system.Following a primary infection, the virus enters the nerves at the site of primary infection, migrates to the cell body of the neuron, and becomes latent in the ganglion.Herpetic keratoconjunctivitis, a primary infection, typically presents as swelling of the conjunctiva and eyelids (blepharoconjunctivitis), accompanied by small white itchy lesions on the surface of the cornea.